Receptor clustering is the most critical step to activate extrinsic apoptosis by death receptors
belonging to the TNF superfamily. Although clinically unsuccessful, using agonist …

Alternative splicing (AS) is a mechanism that generates translational diversity within a
genome. Equally important is the dynamic adaptability of the splicing machinery, which can …

Background Chimeric antigen receptor (CAR)‐T‐cell therapy has transformed cancer
treatment, leading to remarkable clinical outcomes. However, resistance continues to be a …

The majority of clinically approved drugs target proteins that are secreted or cell surface
bound. However, further advances in this area have been hindered by the challenging …

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising
immunotherapeutic strategy for eradicating human cancers. Their therapeutic success and …

Innovative therapeutic strategies are urgently needed to address the ongoing global health
concern of hepatobiliary pancreatic malignancies. This review summarizes the latest and …

Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable
therapeutic effects on haematological malignancies. However, CART cells are less effective …

Bioluminescence imaging is a well-established platform for evaluating engineered cell
therapies in preclinical studies. However, despite the discovery of new luciferases and …