Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases.
Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small …

CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially
identified as a receptor for hyaluronan that participates in both physiological and …

The cell-surface glycoprotein CD44 is involved in a multitude of important physiological
functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte …

The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells.
The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis …

Tissue fibrosis and cancer both lead to high morbidity and mortality worldwide; thus,
effective therapeutic strategies are urgently needed. Because drug resistance has been …

Epithelial mesenchymal transformation plays a crucial role in the metastasis of bladder
cancer, which makes bladder cancer difficult to cure. Bladder cancer is the most common …

Cancer stem cells are a small population of cells with the potential for self-renewal and multi-
directional differentiation and are an important source of cancer initiation, treatment …

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many
different types of cancer and plays a pivotal role in tumor growth and metastasis …