Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

SARS-CoV-2 neutralizing antibodies for COVID-19 prevention and treatment

D Li, GD Sempowski, KO Saunders… - Annual review of …, 2022 - annualreviews.org
Prophylactic and therapeutic drugs are urgently needed to combat coronavirus disease
2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission

B Pickering, O Lung, F Maguire, P Kruczkiewicz… - Nature …, 2022 - nature.com
Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral
variants that can emerge to infect humans. In North America, there is phylogenomic …

Differential antibody response to mRNA COVID-19 vaccines in healthy subjects

SE Wheeler, GV Shurin, M Yost, A Anderson… - Microbiology …, 2021 - Am Soc Microbiol
Knowledge about development and duration of virus-specific antibodies after COVID-19
vaccination is important for understanding how to limit the pandemic via vaccination in …

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu… - Immunity, 2021 - cell.com
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …

A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

G Beaudoin-Bussières, Y Chen, I Ullah, J Prévost… - Cell reports, 2022 - cell.com
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

W Li, Y Chen, J Prévost, I Ullah, M Lu, SY Gong… - Cell reports, 2022 - cell.com
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …

[HTML][HTML] Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

P Zhou, G Song, H Liu, M Yuan, W He, N Beutler, X Zhu… - Immunity, 2023 - cell.com
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly
protective vaccines against novel pandemic coronaviruses and to more effectively respond …

Structure and inhibition of SARS-CoV-2 spike refolding in membranes

MW Grunst, Z Qin, E Dodero-Rojas, S Ding, J Prévost… - Science, 2024 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds the
receptor angiotensin converting enzyme 2 (ACE2) and drives virus-host membrane fusion …

[HTML][HTML] Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses

A Tauzin, SY Gong, G Beaudoin-Bussières, D Vézina… - Cell host & …, 2022 - cell.com
The standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses
administered three weeks apart. However, some public health authorities spaced these …