The role of nicotine and flavor in the abuse potential and appeal of electronic cigarettes for adult current and former cigarette and electronic cigarette users: a …

MS Gades, A Alcheva, AL Riegelman… - Nicotine and Tobacco …, 2022 - academic.oup.com
Introduction Many adult cigarette smokers use electronic cigarettes (e-cigarettes) to cut
down on or quit smoking cigarettes. E-cigarettes with higher abuse potential and appeal …

Gateway effects and electronic cigarettes

JF Etter - Addiction, 2018 - Wiley Online Library
Background E‐cigarettes are alleged to be a gateway to cigarette smoking in non‐smokers.
This study examines whether the gateway theory has value, whether the criteria to establish …

Human abuse liability assessment of tobacco and nicotine products: approaches for meeting current regulatory recommendations

A Vansickel, S Baxter, N Sherwood… - Nicotine and …, 2022 - academic.oup.com
Many regulatory bodies now recommend that tobacco product manufacturers provide
information regarding new tobacco products' abuse liability to inform regulatory …

Presence of the Carcinogen N′-Nitrosonornicotine in Saliva of E-cigarette Users

G Bustamante, B Ma, G Yakovlev… - Chemical research in …, 2018 - ACS Publications
Many harmful constituents are present in e-cigarettes at much lower levels than in cigarette
smoke, and the results of analysis of urinary biomarkers in e-cigarette users are consistent …

Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats

M Javadi-Paydar, TM Kerr, EL Harvey, M Cole… - Drug and alcohol …, 2019 - Elsevier
Background Electronic nicotine delivery systems (ENDS, e-cigarettes) are increasingly used
for the self-administration of nicotine by various human populations, including previously …

Cigarette and e-liquid demand and substitution in e-cigarette-naïve smokers.

JS Stein, MN Koffarnus, I Stepanov… - Experimental and …, 2018 - psycnet.apa.org
Behavioral economic methods allow experimental manipulation of price and examination of
its effects on tobacco product purchasing. These methods may be used to examine tobacco …

Modeling drug exposure in rodents using e-cigarettes and other electronic nicotine delivery systems

C Miliano, ER Scott, LB Murdaugh… - Journal of neuroscience …, 2020 - Elsevier
Smoking tobacco products is the leading cause of preventable death worldwide.
Coordinated efforts have successfully reduced tobacco cigarette smoking in the United …

Dopamine D1‐like receptor activation decreases nicotine intake in rats with short or long access to nicotine

R Chellian, A Behnood‐Rod, R Wilson, K Lin… - Addiction …, 2023 - Wiley Online Library
The use of nicotine and tobacco products is highly addictive. The dopaminergic system
plays a key role in the initiation and maintenance of nicotine intake. Dopamine D1‐like …

Withdrawal from repeated nicotine vapor exposure increases somatic signs of physical dependence, anxiety-like behavior, and brain reward thresholds in adult male …

M Martinez, VE Espinoza, V Garcia, KP Uribe… - …, 2023 - Elsevier
Nicotine vapor consumption via electronic nicotine delivery systems has increased over the
last decade. While prior work has shed light on the health effects of nicotine vapor …

Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats

Y Swain, P Muelken, A Skansberg, D Lanzdorf… - …, 2020 - Springer
Rationale Understanding factors contributing to individual differences in vulnerability to
opioid addiction is essential for developing more effective preventions and treatments, yet …