Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

Ceramides are sphingolipids and integral components of the eukaryotic cell membrane.
Apart from providing structural integrity, ceramides have also been shown to act as second …

In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 …

BACKGROUND Ceramides are sphingolipids that play causative roles in diabetes and heart
disease, with their serum levels measured clinically as biomarkers of cardiovascular disease …

Objective Ectopic fat deposition is associated with increased tissue production of ceramides.
Recent genetic mouse studies suggest that specific sphingolipid C16: 0 ceramide produced …

The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …

Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity,
fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis …

Dysregulation of lipid metabolism plays a major role in the etiology and sequelae of
inflammatory disorders, cardiometabolic and neurological diseases, and several forms of …

Ceramides, composed of a sphingosine and a fatty acid, are bioactive lipid molecules
involved in many key cellular pathways (eg, apoptosis, oxidative stress and inflammation) …

Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD) and
atherosclerotic cardiovascular disease (ASCVD). These diseases share common …