All living cells interact dynamically with a constantly changing world. Eukaryotes, in
particular, evolved radically new ways to sense and react to their environment. These …

The first genuine high-resolution single particle cryo-electron microscopy structure of a
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …

The recent proliferation of published TRP channel structures provides a foundation for
understanding the diverse functional properties of this important family of ion channel …

Transient receptor potential (TRP) proteins are a large family of cation-selective channels,
surpassed in variety only by voltage-gated potassium channels. Detailed molecular …

Membrane proteins exist within the highly hydrophobic membranes surrounding cells and
organelles, playing key roles in cellular function. It is becoming increasingly clear that the …

Over the past decade, the structural biology of membrane proteins (MPs) has taken a new
turn thanks to epoch-making technical progress in single-particle electron cryo-microscopy …

Epithelial calcium channel TRPV6 is a member of the vanilloid subfamily of TRP channels
that is permeable to cations and highly selective to Ca2+; it shows constitutive activity …

Membrane proteins have a range of crucial biological functions and are the target of about
60% of all prescribed drugs. For most studies, they need to be extracted out of the lipid …

The antagonistic bacterium Pseudomonas protegens secretes the cyclic lipopeptide (CLiP)
orfamide A, which triggers a Ca2+ signal causing rapid deflagellation of the microalga …

Transient receptor potential (TRP) or transient receptor potential channels are a highly
diverse family of mostly non-selective cation channels. In the mammalian genome, 28 …