Our understanding of gene expression has changed dramatically over the past decade,
largely catalysed by technological developments. High-throughput experiments …

Abstract Purpose of Review The recent rise of young individuals under age 50 with
colorectal cancer (CRC) is a startling trend in need of greater focus and research. The …

Widespread changes to DNA methylation and chromatin are well documented in cancer, but
the fate of higher-order chromosomal structure remains obscure. Here we integrated …

Colorectal cancer (CRC) develops through a multistage process that results from the
progressive accumulation of genetic mutations, and frequently as a result of mutations in the …

Colorectal cancer (CRC) is one of the most common causes of death, despite decades of
research. Initially considered as a disease due to genetic mutations, it is now viewed as a …

Epigenetics acts as an interface between environmental/exogenous factors, cellular
responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of …

Abstract Background Aberrant CpG island promoter DNA hypermethylation is frequently
observed in cancer and is believed to contribute to tumor progression by silencing the …

Illumina's Infinium HumanMethylation450 BeadChip arrays were used to examine genome-
wide DNA methylation profiles in 22 sample pairs from colorectal cancer (CRC) and …

Regular use of aspirin reduces incidence and mortality of various cancers, including
colorectal cancer. Anticancer effect of aspirin represents one of the 'Provocative Questions' …

BACKGROUND: National databases show a recent significant increase in the incidence of
colorectal cancer in people younger than 50. With current recommendations to begin …