A review on advances of treatment modalities for Alzheimer's disease

ES Thoe, A Fauzi, YQ Tang, S Chamyuang, AYY Chia - Life sciences, 2021 - Elsevier
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Aducanumab therapy to treat Alzheimer's disease: a narrative review

SA Beshir, AM Aadithsoorya, A Parveen… - International Journal …, 2022 - Wiley Online Library
Background. Aducanumab, a new monoclonal antibody that targets β‐amyloid aggregates,
has been granted conditional approval by the US FDA for treatment of mild Alzheimer's …

Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer's disease

R Taliyan, V Kakoty, KC Sarathlal… - Journal of Controlled …, 2022 - Elsevier
For the past several years, dementia, is one of the predominantly observed groups of
symptoms in a geriatric population. Alzheimer's disease (AD) is a progressive memory …

[HTML][HTML] The Contribution of the Locus Coeruleus–Noradrenaline System Degeneration during the Progression of Alzheimer's Disease

D Mercan, MT Heneka - Biology, 2022 - mdpi.com
Abstract Alzheimer's disease (AD), which is characterized by extracellular accumulation of
amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most …

Recent advances in lentiviral vectors for gene therapy

X Wang, C Ma, R Rodríguez Labrada, Z Qin… - Science China Life …, 2021 - Springer
Lentiviral vectors (LVs), derived from human immunodeficiency virus, are powerful tools for
modifying the genes of eukaryotic cells such as hematopoietic stem cells and neural cells …

Virus-based biological systems as next-generation carriers for the therapy of central nervous system diseases

I Nowak, M Madej, J Secemska, R Sarna… - Pharmaceutics, 2023 - mdpi.com
Central nervous system (CNS) diseases are currently a major challenge in medicine. One
reason is the presence of the blood–brain barrier, which is a significant limitation for …

Modification of the gut microbiome to combat neurodegeneration

AO Sasmita - Reviews in the Neurosciences, 2019 - degruyter.com
The gut microbiome was extensively researched for its biological variety and its potential
role in propagating diseases outside of the gastrointestinal (GI) tract. Recently, a lot of effort …

The role of viruses in cancer development versus cancer therapy: An oncological perspective

H Javid, A Sharbaf Mashhad, S Yazdani… - Cancer …, 2023 - Wiley Online Library
Despite great medical advances, oncological research is still looking for novel therapeutic
approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of …

Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases

Y Qu, Y Liu, AF Noor, J Tran, R Li - Neural Regeneration …, 2019 - journals.lww.com
Common neurodegenerative diseases of the central nervous system are characterized by
progressive damage to the function of neurons, even leading to the permanent loss of …

Preparation of PEI‐modified nanoparticles by dopamine self‐polymerization for efficient DNA delivery

L Liu, Z Yang, C Liu, M Wang… - … and Applied Biochemistry, 2023 - Wiley Online Library
Achieving efficient and safe gene delivery is of great significance to promote the
development of gene therapy. In this work, a polydopamine (PDA) layer was coated on the …