Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The
standard of care offers minimal clinical benefit, and most GBM patients experience tumor …

Immunotherapy is regarded as one of the most promising approaches for treating tumors,
with a multitude of immunotherapeutic thoughts currently under consideration for the lethal …

Glioblastoma (GBM) tumors are the most aggressive primary brain tumors in adults that,
despite maximum treatment, carry a dismal prognosis. GBM tumors exhibit tissue hypoxia …

Glioblastoma (GBM), an aggressive brain malignancy with a cellular hierarchy dominated by
GBM stem cells (GSCs), evades antitumor immunity through mechanisms that remain …

Tumor-associated macrophages and microglia (TAMs) are critical for tumor progression and
therapy resistance in glioblastoma (GBM), a type of incurable brain cancer. We previously …

Developing endogenous hyperthermia offers a promising strategy to address challenges
with current exogenous hyperthermia techniques in clinics. Herein, a CD44-targeted and …

Lactate-enriched tumor microenvironment (TME) fosters an immunosuppressive milieu to
hamper the functionality of tumor-associated macrophages (TAMs). However, tackling the …

Identifying definitive biomarkers that predict clinical response and resistance to
immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in …

Although cancer has long been considered a genetic disease, increasing evidence shows
that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic …

Glioblastoma is the most aggressive and fatal brain cancer, characterized by a high growth
rate, invasiveness, and treatment resistance. The presence of the blood–brain barrier (BBB) …