Severe neuropathic pain is a hallmark of Fabry disease, a genetic disorder caused by a
deficiency in lysosomal α-galactosidase A. Pain experienced by these patients significantly …

Neuro-immune alterations in the peripheral and central nervous system play a role in the
pathophysiology of chronic pain in general, and members of the non-coding RNA (ncRNA) …

Fabry disease (FD) is an X-linked metabolic disease caused by a deficiency in α-
galactosidase A (α-Gal A) activity. This causes accumulation of glycosphingolipids …

Fabry disease, the most common lysosomal storage disease, affects multiple organs and
results in a shortened life span. This disease is caused by a deficiency of the lysosomal …

Fabry disease (FD) is a life-threatening X-linked lysosomal storage disorder caused by α-
galactosidase A (α-GAL) deficiency. Small fiber pathology and pain are major FD symptoms …

Background Fabry disease is a rare, X-linked inherited lysosomal storage disorder, that
manifests as a heterogeneous disease with renal, cardiac and nervous system involvement …

Pain is a clinical condition that is currently of great concern and is often caused by tissue or
nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer …

Gangliosides are abundantly occurring sialylated glycosphingolipids serving diverse
functions in the nervous system. Membrane-localized gangliosides are important …

Fabry disease is a progressive X-linked lysosomal storage disease caused by a mutation in
the GLA gene, encoding the lysosomal hydrolase α-galactosidase A. The consequent …

Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid
metabolism due to deficient or absent lysosomal α-galactosidase A (α-Gal A) activity which …