The integral role of RNA in stress granule formation and function

D Campos-Melo, ZCE Hawley… - Frontiers in Cell and …, 2021 - frontiersin.org
Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Negri bodies and other virus membrane-less replication compartments

Q Nevers, AA Albertini, C Lagaudrière-Gesbert… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Viruses reshape the organization of the cell interior to achieve different steps of their cellular
cycle. Particularly, viral replication and assembly often take place in viral factories where …

Structural and functional aspects of Ebola virus proteins

S Jain, E Martynova, A Rizvanov, S Khaiboullina… - Pathogens, 2021 - mdpi.com
Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented,
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …

New perspectives on the biogenesis of viral inclusion bodies in negative-sense RNA virus infections

O Dolnik, GK Gerresheim, N Biedenkopf - Cells, 2021 - mdpi.com
Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

Navigating the complex landscape of ebola infection treatment: A review of emerging pharmacological approaches

F Almeida-Pinto, R Pinto, J Rocha - Infectious Diseases and Therapy, 2024 - Springer
In 1976 Ebola revealed itself to the world, marking the beginning of a series of localized
outbreaks. However, it was the Ebola outbreak that began in 2013 that incited fear and …

Melatonin: Regulation of viral phase separation and Epitranscriptomics in post-acute sequelae of COVID-19

D Loh, RJ Reiter - International journal of molecular sciences, 2022 - mdpi.com
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure
on herd immunity and demands versatile adaptations by the human host genome to counter …

Evidence for viral mRNA export from Ebola virus inclusion bodies by the nuclear RNA export factor NXF1

L Wendt, J Brandt, DS Ushakov, BS Bodmer… - Journal of …, 2022 - Am Soc Microbiol
Many negative-sense RNA viruses, including the highly pathogenic Ebola virus (EBOV), use
cytoplasmic inclusion bodies (IBs) for viral RNA synthesis. However, it remains unclear how …

Drug repurposing for COVID-19 using computational screening: Is Fostamatinib/R406 a potential candidate?

S Saha, AK Halder, SS Bandyopadhyay, P Chatterjee… - Methods, 2022 - Elsevier
With the gradual increase in the COVID-19 mortality rate, there is an urgent need for an
effective drug/vaccine. Several drugs like Remdesivir, Azithromycin, Favirapir, Ritonavir …

Ebola virus inclusion body formation and RNA synthesis are controlled by a novel domain of nucleoprotein interacting with VP35

T Miyake, CM Farley, BE Neubauer… - Journal of …, 2020 - Am Soc Microbiol
Ebola virus (EBOV) inclusion bodies (IBs) are cytoplasmic sites of nucleocapsid formation
and RNA replication, housing key steps in the virus life cycle that warrant further …

Ebola virus inclusion bodies are liquid organelles whose formation is facilitated by nucleoprotein oligomerization

BS Bodmer, M Vallbracht, DS Ushakov… - Emerging Microbes & …, 2023 - Taylor & Francis
Viral RNA synthesis of several non-segmented, negative-sense RNA viruses (NNSVs) takes
place in inclusion bodies (IBs) that show properties of liquid organelles, which are formed by …