The vascular endothelium has several important functions, including hemostasis. The
homeostasis of hemostasis is based on a fine balance between procoagulant and …

Coagulation factor (F) V is a glycoprotein that plays an essential role in the formation of the
prothrombinase complex, which is critical for progressing clot formation. FV deficiency is a …

Proteostasis, ie, the homeostasis of proteins, responsible for ensuring protein turnover, is
regulated by proteases, which also participate in the etiopathogenesis of multiple conditions …

Although a critical therapy in the management of hospitalized pediatric patients, 1, 2
transfusion of red blood cells (RBCs), platelets, and fresh frozen plasma (FFP) in neonatal …

ABSTRACT Background: Rare bleeding disorders (RBDs) are heterogeneous disorders,
mostly inherited in an autosomal recessive pattern. Iran is a Mideast country with a high rate …

Background: The object of this paper was to provide an overview of rare diseases (RDs) with
periodontal manifestations and allocate them to relevant categories. Methods: In ROMSE, a …

Factor V is an essential clotting factor that plays a key role in the blood coagulation cascade
on account of its procoagulant and anticoagulant activity. Eighty percent of circulating factor …

Intracranial hemorrhage (ICH), as a life-threatening bleeding among all kinds of congenital
bleeding disorders (CBDs), is a rare manifestation except in factor XIII (FXIII) deficiency …

Patient blood management (PBM) strategies are needed in the neonate and paediatric
population, given that haemoglobin thresholds used are often higher than recommended by …

Acquired factor V inhibitor (AFVI) is an extremely rare disorder that may cause severe
bleeding. To identify factors associated with bleeding risk in AFVI patients, a national …