The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated
anabolic program in response to growth-promoting signals. Paradoxically, recent studies …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

The mechanistic/mammalian target of rapamycin (mTOR) plays a master role in cell
proliferation and growth in response to insulin, amino acids, energy levels, and oxygen …

The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves
as a key conduit between growth signals and the metabolic processes underlying cell …

More than 20 years after its discovery, our understanding of target of rapamycin (TOR)
signalling continues to grow. Recent global'omics' studies have revealed physiological roles …