Timing of lifespan influences on brain and cognition

KB Walhovd, M Lövden, AM Fjell - Trends in cognitive sciences, 2023 - cell.com
Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

How does it STAC up? Revisiting the scaffolding theory of aging and cognition

PA Reuter-Lorenz, DC Park - Neuropsychology review, 2014 - Springer
Abstract “The Scaffolding Theory of Aging and Cognition (STAC)”, proposed in 2009, is a
conceptual model of cognitive aging that integrated evidence from structural and functional …

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

AM Fjell, L McEvoy, D Holland, AM Dale… - Progress in …, 2014 - Elsevier
What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

Successful memory aging

L Nyberg, S Pudas - Annual review of psychology, 2019 - annualreviews.org
For more than 50 years, psychologists, gerontologists, and, more recently, neuroscientists
have considered the possibility of successful aging. How to define successful aging remains …

[HTML][HTML] Longitudinal association between hippocampus atrophy and episodic-memory decline

T Gorbach, S Pudas, A Lundquist, G Orädd… - Neurobiology of …, 2017 - Elsevier
There is marked variability in both onset and rate of episodic-memory decline in aging.
Structural magnetic resonance imaging studies have revealed that the extent of age-related …

[HTML][HTML] Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studies

L Nyberg, CJ Boraxbekk, DE Sörman, P Hansson… - Ageing research …, 2020 - Elsevier
Individual differences in cognitive performance increase with advancing age, reflecting
marked cognitive changes in some individuals along with little or no change in others …

[HTML][HTML] Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project

M Garo-Pascual, C Gaser, L Zhang, J Tohka… - The Lancet Healthy …, 2023 - thelancet.com
Background Cognitive abilities, particularly memory, normally decline with age. However,
some individuals, often designated as superagers, can reach late life with the memory …

Youthful brains in older adults: preserved neuroanatomy in the default mode and salience networks contributes to youthful memory in superaging

FW Sun, MR Stepanovic, J Andreano… - Journal of …, 2016 - Soc Neuroscience
Decline in cognitive skills, especially in memory, is often viewed as part of “normal” aging.
Yet some individuals “age better” than others. Building on prior research showing that …

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N= 53 949)

G Davies, N Armstrong, JC Bis, J Bressler… - Molecular …, 2015 - nature.com
General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …

Association of cardiovascular risk trajectory with cognitive decline and incident dementia

B Farnsworth von Cederwald, M Josefsson, A Wåhlin… - Neurology, 2022 - AAN Enterprises
Background and Objectives Cardiovascular risk factors have a recently established
association with cognitive decline and dementia, yet most studies examine this association …