Lung cancer is an umbrella term for a subset of heterogeneous diseases that are collectively
responsible for the most cancer-related deaths worldwide. Despite the tremendous progress …

Importance of the field: Sulf-1 and Sulf-2 are sulfatases that edit the sulfation status of
heparan sulfate proteoglycans (HSPGs) on the outside of cells and regulate a number of …

Abstract We analyzed transcriptomes (n= 211), whole exomes (n= 99) and targeted exomes
(n= 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …

Malignant pleural mesothelioma (MPM) is recognized as heterogeneous based both on
histology and molecular profiling. Histology addresses inter-tumor and intra-tumor …

TAMs, a unique and distinct M2-skewed myeloid population of tumor stroma, exhibiting pro-
tumor functions is fast emerging as a potential target for anti-cancer immunotherapy …

Activation of the stimulator of interferon genes (STING) pathway promotes antitumor
immunity but STING agonists have yet to achieve clinical success. Increased understanding …

Most gene expression profiling studies of mesothelioma have been based on relatively
small sample numbers, limiting their statistical power. We did Affymetrix U133A microarray …

The discovery of pathways and regulatory networks whose perturbation contributes to
neoplastic transformation remains a fundamental challenge for cancer biology. We show …

Although mesothelioma is the consequence of a protracted immune response to asbestos
fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches …

Purpose: Despite research efforts to develop more effective diagnostic and therapeutic
approaches, malignant pleural mesothelioma (MPM) prognosis remains poor. The …