Hemopexin is an acute-phase plasma glycoprotein, produced mainly by the liver and
released into plasma, where it binds heme with high affinity. Other sites of hemopexin …

Hemopexin is a plasma protein that plays a well‐established biological role in sequestering
heme that is released into the plasma from hemoglobin and myoglobin as the result of …

Extracellular hemoglobin, a byproduct of hemolysis, can release its prosthetic heme groups
upon oxidation. This produces metabolically active heme that is exchangeable between …

The development of a heme-responsive biosensor for dynamic pathway regulation in
eukaryotes has never been reported, posing a challenge for achieving the efficient synthesis …

Species specific differences in transporters, chaperones, metal binding proteins and other
targets are important in metal toxicity. Therefore, we have studied the effects of copper …

Copper is essential in a host of biological processes, and disruption of its homeostasis is
associated with diseases including neurodegeneration and metabolic disorders …

The acute phase reaction is an early response aimed at the defence of the organism and at
the re-establishment of homeostasis in response to acute infection, inflammation and other …

Heme, a ferrous iron protoporphyrin IX complex, is employed as a prosthetic group in a
number of diverse heme proteins that participate in important cellular and systemic …

Studies with patients, animal models of human disease and hemopexin null mice have
shown that the heme-binding protein hemopexin is vital for the protection of a variety of cell …

Haem (iron‐protoporphyrin IX) is vital to aerobic life. However, haemolysis generates
massive amounts of free haem that can be maintained for several days. Haem is toxic …