Predicting drug–target interactions (DTIs) is crucial in innovative drug discovery, drug
repositioning and other fields. However, there are many shortcomings for predicting DTIs …

Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer with a
mortality rate of approximately 3–6/100,000 and is the third leading cause of cancer-related …

Background Biomedical knowledge graphs have become important tools to computationally
analyse the comprehensive body of biomedical knowledge. They represent knowledge as …

Target selection is the first and pivotal step in drug discovery. An incorrect choice may not
manifest itself for many years after hundreds of millions of research dollars have been spent …

Clinical trials offer a fundamental opportunity to discover new treatments and advance the
medical knowledge. However, the uncertainty of the outcome of a trial can lead to …

A novel nanoformulation, C 60 fullerene loaded with a plant alkaloid Piperlongumine (PL)
molecules (C 60-PL nanocomplex), as a potential drug for the treatment of highly metastatic …

Sarcomas are a group of malignant neoplasms of connective tissue with a different etiology
than carcinomas. The efforts to discover new drugs with antisarcoma activity have generated …

The annotation of entities with concepts from standardized terminologies and ontologies is
of high importance in the life sciences to enhance semantic interoperability, information …

Four new daphnane-type diterpenes named tianchaterpenes CF (1–4) and six known ones
were isolated from Stelleropsis tianschanica. Their structures were elucidated based on …

Background Determining which target to pursue is a challenging and error-prone first step in
developing a therapeutic treatment for a disease, where missteps are potentially very costly …