Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …
spine are biomechanically interdependent, typically occur in tandem, and have considerable …
microRNA-181 serves as a dual-role regulator in the development of human cancers
MicroRNAs (miRNAs) as the regulatory short noncoding RNAs are involved in a wide array
of cellular and molecular processes. They negatively regulate gene expression and their …
of cellular and molecular processes. They negatively regulate gene expression and their …
Macrophage migration inhibitory factor drives pathology in a mouse model of spondyloarthritis and is associated with human disease
Spondyloarthritis (SpA), a type 3 immunity-mediated inflammatory arthritis, is a systemic
rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes. Macrophage …
rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes. Macrophage …
microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints
A Nakamura, YR Rampersaud, S Nakamura… - Annals of the …, 2019 - ard.bmj.com
Objectives We recently identified microRNA-181a-5p (miR-181a-5p) as a critical mediator
involved in the destruction of lumbar facet joint (FJ) cartilage. In this study, we tested if …
involved in the destruction of lumbar facet joint (FJ) cartilage. In this study, we tested if …
[HTML][HTML] The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets
H Endisha, J Rockel, I Jurisica, M Kapoor - JCI insight, 2018 - ncbi.nlm.nih.gov
The disabling degenerative disease osteoarthritis (OA) is prevalent among the global
population. Articular cartilage degeneration is a central feature of OA; therefore, a better …
population. Articular cartilage degeneration is a central feature of OA; therefore, a better …
pathDIP: an annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis
S Rahmati, M Abovsky, C Pastrello… - Nucleic acids …, 2017 - academic.oup.com
Molecular pathway data are essential in current computational and systems biology
research. While there are many primary and integrated pathway databases, several …
research. While there are many primary and integrated pathway databases, several …
[HTML][HTML] Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents
Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic
low back pain represent the most common degenerative joint pathologies and are leading …
low back pain represent the most common degenerative joint pathologies and are leading …
MicroRNA-34a and MicroRNA-181a mediate visfatin-induced apoptosis and oxidative stress via NF-κB pathway in human osteoarthritic chondrocytes
S Cheleschi, S Tenti, N Mondanelli, C Corallo… - Cells, 2019 - mdpi.com
Current evidence suggests a complex interaction between adipokines and microRNA
(miRNA) in osteoarthritis (OA) pathogenesis. The present study explored the role of miR-34a …
(miRNA) in osteoarthritis (OA) pathogenesis. The present study explored the role of miR-34a …
[HTML][HTML] The current role of disease-modifying osteoarthritis drugs
EC Rodriguez-Merchan - Archives of Bone and Joint Surgery, 2023 - ncbi.nlm.nih.gov
Contemporary treatments for osteoarthritis (OA) pursue only to alleviate the pain caused by
the illness. Discovering disease-modifying osteoarthritis drugs (DMOADs) that can induce …
the illness. Discovering disease-modifying osteoarthritis drugs (DMOADs) that can induce …
[HTML][HTML] Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis
Objective MicroRNAs act locally and systemically to impact osteoarthritis (OA)
pathophysiology, but comprehensive profiling of the circulating miRNome in early vs late …
pathophysiology, but comprehensive profiling of the circulating miRNome in early vs late …