Drug discovery is a crucial part of human healthcare and has dramatically benefited human
lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming …

In this Review, we have addressed some recent developments in the discovery and
applications of anti-human immunodeficiency virus type− 1 (HIV− 1) broadly neutralizing …

Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs)
using prime-boost regimens with HIV envelope (Env) immunogens. Epitope mapping has …

Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of
somatic hypermutation within germinal centers (GCs) required for most HIV broadly …

Although the efficacy and commercial success of vaccines and therapeutic antibodies have
been tremendous, designing and discovering new drug candidates remains a labor-, time …

Microscopy has been essential to elucidate micro-and nano-scale processes in space and
time and has provided insights into cell and organismic functions. It is widely employed in …

In the past two decades, there has been an explosion in the discovery of HIV-1 broadly
neutralizing antibodies (bnAbs) and associated vaccine strategies to induce them. This …

Apparent parallels between natural language and antibody sequences have led to a surge
in deep language models applied to antibody sequences for predicting cognate antigen …

Determining the specificity of adaptive immune receptors—B cell receptors (BCRs), their
secreted form antibodies, and T cell receptors (TCRs)—is critical for understanding immune …

Cryogenic electron microscopy (cryo-EM) has become in the past 10 years one of the major
tools for the structure determination of proteins. Nowadays, the structure prediction field is …