The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

For the establishment of a successful infection, ie, long-term parasitism and a complete life
cycle, parasites use various diverse mechanisms and factors, which they may be inherently …

Glycosylation processes are under high natural selection pressure, presumably because
these can modulate resistance to infection. Here, we asked whether inactivation of the UDP …

CD4+ T-cells have been shown to play a central role in immune control of infection with
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …

Plasmodium sporozoites are deposited in the host skin by Anopheles mosquitoes. The
parasites migrate from the dermis to the liver, where they invade hepatocytes through a …

Malaria is caused by Plasmodium protozoa that are transmitted by anopheline mosquitoes.
Plasmodium sporozoites are released with saliva when an infected female mosquito takes a …

Robust tools for analysing gene function in Plasmodium parasites, which are the causative
agents of malaria, are being developed at an accelerating rate. Two decades after genetic …

Plasmodium sporozoites are the crescent-shaped forms of malaria parasites injected from
the salivary glands of mosquitoes into the skins of their vertebrate hosts. To proceed towards …

Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

Malaria causes high levels of morbidity and mortality in human beings worldwide. According
to the World Health Organization (WHO), about half a million people die of this disease each …