Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Importance Trends in type 2 diabetes show an increase in prevalence along with younger
age of onset. While vascular complications of early-onset type 2 diabetes are known, the …

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by
the aging neurovascular unit being confronted with and failing to cope with biological insults …

Hypertension is a highly prevalent condition which has been established as a risk factor for
cardiovascular and cerebrovascular disease. Although the understanding of the relationship …

Background In recently, several large longitudinal population-based studies have shown
that the rate of cognitive decline is accelerated in elderly people with diabetes mellitus. But …

Importance Converging evidence suggests that Alzheimer disease (AD) involves insulin
signaling impairment. Patients with AD and individuals at risk for AD show reduced glucose …

Background Gender-specific risks for dementia and Alzheimer's disease (AD) starting in
midlife remain largely unknown. Methods Prospectively ascertained dementia/AD and cause …

Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease
(AD) plaguing the elderly population. VaD is a progressive disease caused by reduced …

More than 25 million people in the world today are affected by dementia, most suffering from
Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has …