Founder mutations are disease-causing variants that occur frequently in geographically or
culturally isolated groups whose shared ancestor (s) carried the pathogenic variant. While …

To leverage the genetic diversity in Nigeria, we established the Non-Communicable
Diseases Genetic Heritage Study (NCD-GHS) consortium to help produce a comprehensive …

Despite recent biomedical breakthroughs and large genomic studies growing momentum,
the Middle Eastern population, home to over 400 million people, is underrepresented in the …

Genotype imputation is now fundamental for genome-wide association studies but lacks
fairness due to the underrepresentation of references from non-European ancestries. The …

Background Disparities in the genetic risk of cancer among various ancestry groups and
populations remain poorly defined. This challenge is even more acute for Middle Eastern …

Mapping the Arab genome | Nature Genetics Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the …

The Y-chromosome has been widely used in forensic genetic applications and human
population genetic studies due to its uniparental origins. A large database on the Qatari …

Pharmacogenetic (PGx)‐informed medication prescription is a cutting‐edge genomic
application in contemporary medicine, offering the potential to overcome the conventional …

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits
in social communication, restricted interests, and repetitive behaviors. Despite considerable …

Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations,
but pathogenic risk variants that cause SGDs are typically population-private. The goal was …