Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …

Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …

Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous
neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Conspectus The interaction of d-block metal ions (Cu, Zn, Fe, etc.) with intrinsically
disordered proteins (IDPs) has gained interest, partly due to their proposed roles in several …

Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

We report on a concept that some of us first described a decade ago for pure electron
transfer [V. Balland, C. Hureau and J.-M. Savéant, Proc. Natl. Acad. Sci. USA, 2010, 107 …

The equilibrium of metal ions is critical for many physiological functions, particularly in the
central nervous system, where metals are essential for development and maintenance of …