Molecular and cellular paradigms of multidrug resistance in cancer

FU Vaidya, A Sufiyan Chhipa, V Mishra… - Cancer …, 2022 - Wiley Online Library
Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …

Multidrug resistance proteins (MRPs) and cancer therapy

YK Zhang, YJ Wang, P Gupta, ZS Chen - The AAPS journal, 2015 - Springer
The ATP-binding cassette (ABC) transporters are members of a protein superfamily that are
known to translocate various substrates across membranes, including metabolic products …

Analysis of the intricate relationship between chronic inflammation and cancer

EZP Chai, KS Siveen, MK Shanmugam… - Biochemical …, 2015 - portlandpress.com
Deregulated inflammatory response plays a pivotal role in the initiation, development and
progression of tumours. Potential molecular mechanism (s) that drive the establishment of …

Role of multidrug resistance-associated proteins in cancer therapeutics: past, present, and future perspectives

A Elfadadny, HM El-Husseiny, A Abugomaa… - … Science and Pollution …, 2021 - Springer
Cancer, a major public health problem, is one of the world's top leading causes of death.
Common treatments for cancer include cytotoxic chemotherapy, surgery, targeted drugs …

A review on the antitumor activity of various nitrogenous-based heterocyclic compounds as NSCLC inhibitors

JC Liu, S Narva, K Zhou… - Mini Reviews in Medicinal …, 2019 - ingentaconnect.com
At present, cancers have been causing deadly fears to humans and previously
unpredictable losses to health. Especially, lung cancer is one of the most common causes of …

The effects of drug transporters on the efficacy of methotrexate in the treatment of rheumatoid arthritis

J Gao, C Wang, W Wei - Life Sciences, 2021 - Elsevier
The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of
common drug transporters that mediate the efflux and uptake of drugs, respectively, and play …

The emerging role of COX-2, 15-LOX and PPARγ in metabolic diseases and cancer: an introduction to novel multi-target directed ligands (MTDLs)

RA Alaaeddine, PA Elzahhar, I AlZaim… - Current Medicinal …, 2021 - ingentaconnect.com
Emerging evidence supports an intertwining framework for the involvement of different
inflammatory pathways in a common pathological background for a number of disorders. Of …

Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3β and β-catenin pathway in A549 cell line

D Eren, YM Betul - Chemico-Biological Interactions, 2016 - Elsevier
Background and aim In our study, anticancer effects of 6-gingerol, 6-shogaol from ginger
and curcumin from turmeric were investigated and the results were compared with each …

Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom

I Oroz-Parra, M Navarro, KE Cervantes-Luevano… - Toxins, 2016 - mdpi.com
Lung cancer is one of the most common types of cancer in men and women and a leading
cause of death worldwide resulting in more than one million deaths per year. The venom of …

[HTML][HTML] miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells

NJ Monteleone, CS Lutz - Oncotarget, 2020 - ncbi.nlm.nih.gov
Lung cancer is a collection of aggressive tumors generally not diagnosed until late-stage,
resulting in high mortality rates. The vast majority of non-small cell lung cancer (NSCLC) …