Hypoxia is a significant feature of solid tumor cancers. Hypoxia leads to a more malignant
phenotype that is resistant to chemotherapy and radiation, is more invasive and has greater …

Tumor hypoxia is a common feature in most solid tumors and is associated with
overexpression of the hypoxia response pathway. Overexpression of the hypoxia‐inducible …

Animals respond to chronic hypoxia by increasing the levels of a transcription factor known
as the hypoxia‐inducible factor (HIF). HIF upregulates multiple genes, the products of which …

Uveal melanoma is the most common intraocular malignancy although it is a rare subset of
all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with …

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and
patients that develop metastases (~ 50%) survive< 1 year, highlighting the urgent need for …

Dysregulation of transcription is found in nearly every human disease, and as a result there
has been intense interest in developing new therapeutics that target regulators of …

Purpose: Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in
adults. Here, we examined the importance of hypoxia in UM growth and tested the antitumor …

Purpose: The hypoxia-inducible factor-1 (HIF-1) plays a critical role in tumor adaptation to
hypoxia, and its elevated expression correlates with poor prognosis and treatment failure in …

Hypoxia is a common characteristic of many types of solid tumors and is associated with
tumor propagation, malignant progression, and resistance to anti-cancer therapy. HIF-1 …

The hypoxia inducible factor (HIF) pathway is an attractive target for cancer, as it controls
tumor adaptation to growth under hypoxia and mediates chemotherapy and radiation …