Cancer-specific T cells are required for effective anti-cancer immunity and have a central
role in cancer immunotherapy. However, emerging evidence suggests that only a small …

Neoantigen vaccines are based on epitopes of antigenic parts of mutant proteins expressed
in cancer cells. These highly immunogenic antigens may trigger the immune system to …

Immunotherapy has emerged as a highly promising approach in the treatment of epithelial
ovarian cancer (EOC). Immune checkpoint blockade (ICB) therapy, PARP inhibitors …

Therapeutic vaccines are currently at the forefront of medical innovation. Various endeavors
have been made to develop more consolidated approaches to producing nucleic acid …

Background Checkpoint blockade immunotherapy has had a significant impact on the
survival of a subset of patients with advanced cancers. It has been particularly effective in …

Alternatives to conventional cancer treatments are highly sought after for high-risk
malignancies that have a poor response to established treatment modalities. With research …

In the last years, immunotherapies have shown tremendous success as treatments for
multiple types of cancer. However, there are still many obstacles to overcome in order to …

In silico T‐cell epitope prediction plays an important role in immunization experimental
design and vaccine preparation. Currently, most epitope prediction research focuses on …

Mutations of the IL2RG gene, which encodes for the interleukin-2 receptor common gamma
chain (γC, CD132), can lead to X-linked severe combined immunodeficiency (X-SCID) …

Inflammation and tissue damage associated with pancreatitis can precede or occur
concurrently with pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC …