Cancer is characterized by increased oxidative stress, an imbalance between reactive
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …

Superoxide dismutases (SODs) are metalloproteins that protect cells against oxidative stress
by controlling the concentration of superoxide (O 2−) through catalysis of its dismutation. The …

Significance: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous
antioxidant defenses maintaining the steady-state levels of O2·−; no wonder, thus, that their …

Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe
porphyrins (FePs), Mn (III) salens, Mn (II) cyclic polyamines and metal salts. Due to their …

Significance: Ionizing radiation is a vital component in the oncologist's arsenal for the
treatment of cancer. Approximately 50% of all cancer patients will receive some form of …

Mn (III) ortho‐N‐alkyl‐and N‐alkoxyalkyl porphyrins (MnPs) were initially developed as
superoxide dismutase (SOD) mimics. These compounds were later shown to react with …

Superoxide dismutases play an important role in human health and disease. Three decades
of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn …

Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer
(PCa). However, cancer cells often develop resistance to radiation through unknown …

The current COVID-19 pandemic requires urgent development of effective therapeutics. 5-
amino levulinic acid (5-ALA) is a naturally synthesized amino acid and has been used for …