The role of CYP3A in health and disease
LS Klyushova, ML Perepechaeva, AY Grishanova - Biomedicines, 2022 - mdpi.com
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
Therapeutic protein drug interactions: a white paper from the international consortium for innovation and quality in pharmaceutical development
DE Coutant, DW Boulton, UP Dahal… - Clinical …, 2023 - Wiley Online Library
Typically, therapeutic proteins (TPs) have a low risk for eliciting meaningful drug interactions
(DIs). However, there are select instances where TP drug interactions (TP‐DIs) of clinical …
(DIs). However, there are select instances where TP drug interactions (TP‐DIs) of clinical …
Altered bioavailability and pharmacokinetics in Crohn's disease: capturing systems parameters for PBPK to assist with predicting the fate of orally administered drugs
Abstract Backgrond and Objective Crohn's disease (CD) is a chronic inflammatory bowel
disease that affects a wide age range. Hence, CD patients receive a variety of drugs over …
disease that affects a wide age range. Hence, CD patients receive a variety of drugs over …
Potential Dietary and Therapeutic Strategies Involving Indole-3-Carbinole in Preclinical Models of Intestinal Inflammation
A Qazi, S Comiskey, N Calzadilla, F Amin, A Sharma… - Nutrients, 2023 - mdpi.com
Diet–microbiota interactions are emerging as important contributors in the pathogenesis of
inflammatory bowel diseases (IBD), characterized by chronic inflammation of the GI tract …
inflammatory bowel diseases (IBD), characterized by chronic inflammation of the GI tract …
Potential and challenges in application of physiologically based pharmacokinetic modeling in predicting diarrheal disease impact on oral drug pharmacokinetics
CX Zhang, SLM Arnold - Drug Metabolism and Disposition, 2024 - Elsevier
Physiologically based pharmacokinetic (PBPK) modeling is a physiologically relevant
approach that integrates drug-specific and system parameters to generate pharmacokinetic …
approach that integrates drug-specific and system parameters to generate pharmacokinetic …
Characterization of the mucosally-adherent duodenal microbiome in children with and without Crohn's disease
K Schmidt, J Noel-MacDonnell, C Vyhlidal, DP Heruth… - Pharmaceuticals, 2022 - mdpi.com
Manipulation of the microbiome is a rational treatment strategy for inflammatory bowel
disease (IBD). Compared to the colon and terminal ileum (TI), understanding of the microbial …
disease (IBD). Compared to the colon and terminal ileum (TI), understanding of the microbial …
Pharmacogenetic testing for the pediatric gastroenterologist: Actionable drug–gene pairs to know
T Sandritter, R Chevalier, R Abt, V Shakhnovich - Pharmaceuticals, 2023 - mdpi.com
Gastroenterologists represent some of the earlier adopters of precision medicine through
pharmacogenetic testing by embracing upfront genotyping for thiopurine S …
pharmacogenetic testing by embracing upfront genotyping for thiopurine S …
Cytochrome P450 enzymes in the pediatric population: Connecting knowledge on P450 expression with pediatric pharmacokinetics
C Emoto, TN Johnson - Advances in Pharmacology, 2022 - Elsevier
Cytochrome P450 enzymes play an important role in the pharmacokinetics, efficacy, and
toxicity of drugs. Age-dependent changes in P450 enzyme expression have been studied …
toxicity of drugs. Age-dependent changes in P450 enzyme expression have been studied …
Impact of Duodenal Pathology on Oral Drug Bioavailability and Disease Outcomes in Pediatric Crohn's Disease
R Casini, CA Vyhlidal, JM Bracken, AK Sherman… - Pharmaceuticals, 2023 - mdpi.com
Background: Crohn's disease with upper gastrointestinal tract involvement occurs more
often in children than adults and has the potential to interfere with oral drug absorption. We …
often in children than adults and has the potential to interfere with oral drug absorption. We …
Distribution Characteristics and Impacting Factors of Drug CYP Enzymes and Transporters in the Gastrointestinal Tract of Chinese Healthy Subjects
The abundance of drug metabolic enzymes (DMEs) and transporters (DTs) in the human
gastrointestinal tract significantly affects xenobiotic exposure in the circulating system, the …
gastrointestinal tract significantly affects xenobiotic exposure in the circulating system, the …