Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

Different types of cell behavior, including growth, motility, and navigation, require actin
proteins to assemble into filaments. Here, we describe a biochemical process that was able …

Developing neurons use a combination of guidance cues to assemble a functional neural
network. A variety of proteins immobilized within the extracellular matrix (ECM) provide …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

The semaphorins, originally discovered as evolutionarily conserved steering molecules for
developing axons, also influence neuronal structure and function in the early postnatal and …

Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …

Semaphorin 3E (Sema3E) is a secreted molecule implicated in axonal path finding and
inhibition of developmental and postischemic angiogenesis. Sema3E is also highly …

Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family
kinases (SFKs) involved in multiple transduction pathways in the central nervous system …

Semaphorins are the products of a large gene family containing 28 genes of which 21 are
found in vertebrates. Class-3 semaphorins constitute a subfamily of seven vertebrate …