Technological advances enabling massively parallel measurement of biological features—
such as microarrays, high-throughput sequencing and mass spectrometry—have ushered in …

Covering: up to 2022 With the emergence of large amounts of omics data, computational
approaches for the identification of plant natural product biosynthetic pathways and their …

Sexually dimorphic traits are common among mammals and are specified during
development through the deployment of sex-specific genetic programs. Because little is …

Significant innovations in next-generation sequencing techniques and bioinformatics tools
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …

Temporal changes to the concentration of molecular species such as mRNA, which take
place in response to various environmental cues, can often be modeled as simple …

As boreal forests face significant threats from climate change, understanding evolutionary
trajectories of coniferous species has become fundamental to adapting management and …

A proper understanding of disease etiology will require longitudinal systems-scale
reconstruction of the multitiered architecture of eukaryotic signaling. Here we combine state …

To investigate molecular mechanisms underlying cell state changes, a crucial analysis is to
identify differentially expressed (DE) genes along the pseudotime inferred from single-cell …

Genetic variation is the raw material upon which selection acts. The majority of
environmental conditions change over time and therefore may result in variable selective …

Background High-throughput RNA sequencing (RNA-seq) has evolved as an important
analytical tool in molecular biology. Although the utility and importance of this technique …