Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

Abstract Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved
phosphotransferase that converts the purine ribonucleoside adenosine into 5′-adenosine …

By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …

The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the
adenosine A1, A2A, A2B, and A3 receptor. They are all G protein-coupled receptors (GPCR) …

Cardiomyocytes and vascular cells readily form, transport, and metabolize the endogenous
adenine nucleoside adenosine and act to regulate both interstitial and plasma adenosine …

Stem cells maintain populations of highly differentiated, short-lived cell-types, including
blood, skin and sperm, throughout adult life. Understanding the mechanisms that regulate …