Nicotine withdrawal is associated with deficits in neurocognitive function including sustained
attention, working memory, and response inhibition. Several convergent lines of evidence …

Evidence from lesion and cortical-slice studies implicate the neocortical cholinergic system
in the modulation of sensory, attentional and memory processing. In this review we consider …

Smokers have substantial individual differences in quit success in response to current
treatments for nicotine dependence. This observation may suggest that different underlying …

Smoking is usually initiated in adolescence, and is the leading preventable cause of death
in the United States. Little is known, however, about the links between smoking and …

Previous research suggests that a history of early life stress (ELS) impacts working memory
(WM) in adulthood. Despite the widespread use of WM paradigms, few studies have …

Neuroeconomics integrates behavioral economics and cognitive neuroscience to
understand the neurobiological basis for normative and maladaptive decision making. Delay …

Prefrontal cortex executive functions, such as working memory (WM) interact with limbic
processes to foster impulse control. Such an interaction is referred to in a growing body of …

Introduction: Non-motor symptoms of Parkinson's disease (PD) have become increasingly
recognized as central to the disease. These include somatic symptoms, such as pain and …

The basal forebrain cholinergic neurons provide acetylcholine to the cortex via large
projections. Recent molecular imaging work in humans indicates that the cortical cholinergic …

Background Nicotine dependence is difficult to treat, and the biological mechanisms that are
involved are not entirely clear. There is an urgent need to develop better drugs and more …