Much of natural product chemistry concerns a group of compounds known as secondary
metabolites. These low-molecular-weight metabolites often have potent physiological …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

A gene encoding a putative dimodular nonribosomal peptide synthetase (NRPS) was
identified within a gene cluster of Aspergillus fumigatus, a species reported to produce …

Arthrofactin is a potent cyclic lipopeptide-type biosurfactant produced by Pseudomonas sp.
MIS38. In this work, an arthrofactin synthetase gene cluster (arf) spanning 38.7 kb was …

Enzyme redesign refers to the ability to rationally alter enzyme structure to cause a predicted
change in function. This article discusses challenges facing the designer and the available …

The realm of natural products of early diverging fungi such as Mortierella species is largely
unexplored. Herein, the nonribosomal peptide synthetase (NRPS) MalA catalysing the …

Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous
oxidase isopenicillin N synthase (IPNS) play crucial roles in the biosynthesis of β-lactam ring …

Microbial nonribosomally processed peptides represent a large class of natural products
including numerous important pharmaceutical agents, as well as other representatives that …

Peptides like penicillin or cyclosporin are nonribosomally synthesised by large
multifunctional enzymes. Peptide synthetase genes are coexpressed with other biosynthesis …

Acremoniumchrysogenum. Otheranalogoustripeptides andtetrapeptides werelater reported
in these and other/3-lactam producing fungi and actinomycetes. TheACVtripeptide is …