Publisher Summary It is clear from the experimental data that there are some similarities in
RNA replication for all eukaryotic positive-stranded RNA viruses—that is, the mechanism of …

Picornaviruses cause several diseases, not only in humans but also in various animal hosts.
For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina …

In positive-stranded viruses, the genomic RNA serves as a template for both translation and
RNA replication. Using poliovirus as a model, we examined the interaction between these …

The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I
and MDA5 in viral infection is much debated. We investigated the roles of each pattern …

The mechanisms and factors involved in the replication of positive stranded RNA viruses are
still unclear. Using poliovirus as a model, we show that a long-range interaction between …

Replication of positive strand flaviviruses is mediated by the viral RNA-dependent RNA
polymerases (RdRP). To study replication of dengue virus (DEN), a flavivirus family member …

ABSTRACT Sequences in the 5′ and 3′ termini of plus-strand RNA viruses harbor cis-
acting elements important for efficient translation and replication. In case of the hepatitis C …

RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that
is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid …

Some 20 years ago, the study of picornaviral RNA translation led to the characterization of
an alternative mechanism of initiation by direct ribosome binding to the 5′ UTR. By using a …

The poly (rC) binding protein (PCBP) is a cellular protein required for poliovirus replication.
PCBP specifically interacts with two domains of the poliovirus 5′ untranslated region (5 …