Following a diagnosis of breast cancer, the most immediate challenges in patient
management are the determination of prognosis and identification of the most appropriate …

Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

Exosomes are emerging as important mediators of the cross-talk between tumor cells and
the microenvironment. However, the mechanisms by which exosomes modulate tumor …

Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

Cancer remains one of the most challenging diseases, as many patients show limited
therapeutic response to treatment. Liquid biopsy is a minimally invasive method that has the …

Most of what is presently known about how miRNAs regulate gene expression comes from
studies that characterized the regulatory effect of miRNA binding sites located in the 3 …

Background The focus of this study is to identify particular microRNA (miRNA) signatures in
exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2) …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

Abstract miRNAs have emerged, in the last decade, as key players in the carcinogenic
process, with many candidates identified as playing important roles in many aspects of …

Breast cancer is the most frequent malignancy diagnosed in women. Approximately 70% of
breast tumors express the estrogen receptor (ER). Tamoxifen and aromatase inhibitors (AIs) …