Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

K Dąbrowska - Medicinal research reviews, 2019 - Wiley Online Library
Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …

Engineered bacteriophage therapeutics: rationale, challenges and future

M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

A roadmap for genome-based phage taxonomy

D Turner, AM Kropinski, EM Adriaenssens - Viruses, 2021 - mdpi.com
Bacteriophage (phage) taxonomy has been in flux since its inception over four decades ago.
Genome sequencing has put pressure on the classification system and recent years have …

Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks

H Bin Jang, B Bolduc, O Zablocki, JH Kuhn… - Nature …, 2019 - nature.com
Microbiomes from every environment contain a myriad of uncultivated archaeal and
bacterial viruses, but studying these viruses is hampered by the lack of a universal, scalable …

INfrastructure for a PHAge REference database: identification of large-scale biases in the current collection of cultured phage genomes

R Cook, N Brown, T Redgwell, B Rihtman, M Barnes… - Phage, 2021 - liebertpub.com
Background: With advances in sequencing technology and decreasing costs, the number of
phage genomes that have been sequenced has increased markedly in the past decade …

Taxonomy of prokaryotic viruses: 2018-2019 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

EM Adriaenssens, MB Sullivan, P Knezevic… - Archives of …, 2020 - Springer
This article is a summary of the activities of the ICTV's Bacterial and Archaeal Viruses
Subcommittee for the years 2018 and 2019. Highlights include the creation of a new order …

Pharmacologically aware phage therapy: pharmacodynamic and pharmacokinetic obstacles to phage antibacterial action in animal and human bodies

K Dąbrowska, ST Abedon - Microbiology and Molecular Biology …, 2019 - Am Soc Microbiol
The use of viruses infecting bacteria (bacteriophages or phages) to treat bacterial infections
has been ongoing clinically for approximately 100 years. Despite that long history, the …

Design and Preclinical Development of a Phage Product for the Treatment of Antibiotic-Resistant Staphylococcus aureus Infections

SM Lehman, G Mearns, D Rankin, RA Cole, F Smrekar… - Viruses, 2019 - mdpi.com
Bacteriophages, viruses that only kill specific bacteria, are receiving substantial attention as
nontraditional antibacterial agents that may help alleviate the growing antibiotic resistance …

Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses

WP Herridge, P Shibu, J O'Shea… - Journal of medical …, 2020 - microbiologyresearch.org
Klebsiella spp. are commensals of the human microbiota, and a leading cause of
opportunistic nosocomial infections. The incidence of multidrug resistant (MDR) strains of …

A hundred years of bacteriophages: Can phages replace antibiotics in agriculture and aquaculture?

C Sieiro, L Areal-Hermida, Á Pichardo-Gallardo… - Antibiotics, 2020 - mdpi.com
Agriculture, together with aquaculture, supplies most of the foodstuffs required by the world
human population to survive. Hence, bacterial diseases affecting either agricultural crops …