The mechanism of human immunodeficiency virus 1 (HIV-1) nuclear entry, required for
productive infection, is not fully understood. Here, we report that in HeLa cells and activated …

Rapid progress in gene editing based on clustered regularly interspaced short palindromic
repeats/CRISPR-associated protein (CRISPR/Cas) has revolutionized functional genomic …

Successful antiretroviral therapy (ART) can efficiently suppress Human Immunodeficiency
Virus-1 (HIV-1) replication to undetectable levels, but rare populations of infected memory …

Background The persistence of intact replication-competent HIV-1 proviruses is responsible
for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to …

A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …

HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes.
Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to …

The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts
DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell …

We have designed and characterised PROteolysis TArgeting Chimeras (PROTACs) active
against the human protein cyclophilin A (CypA), a viral cofactor required for efficient …

Upon entry, viruses induce a widespread cellular response that can promote or inhibit
infection. This interaction between viral and cellular factors determines whether the virus is …

Abstract In 2021, 38.4 million people were living with HIV globally. New HIV infections and
AIDS-related deaths are steadily declining due to effective antiretroviral treatment. However …