Microbiome dysbiosis: a pathological mechanism at the intersection of obesity and glaucoma

S Pezzino, M Sofia, LP Greco, G Litrico… - International Journal of …, 2023 - mdpi.com
The rate at which obesity is becoming an epidemic in many countries is alarming. Obese
individuals have a high risk of developing elevated intraocular pressure and glaucoma …

Does CC motif chemokine ligand 2 (CCL2) link obesity to a pro-inflammatory state?

S Dommel, M Blüher - International Journal of Molecular Sciences, 2021 - mdpi.com
The mechanisms of how obesity contributes to the development of cardio-metabolic
diseases are not entirely understood. Obesity is frequently associated with adipose tissue …

Mitochondria at work: new insights into regulation and dysregulation of cellular energy supply and metabolism

V Schirrmacher - Biomedicines, 2020 - mdpi.com
Mitochondria are of great relevance to health, and their dysregulation is associated with
major chronic diseases. Research on mitochondria—156 brand new publications from 2019 …

Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool

TB Scheidl, AL Brightwell, SH Easson, JA Thompson - BMC medicine, 2023 - Springer
Background It is now understood that it is the quality rather than the absolute amount of
adipose tissue that confers risk for obesity-associated disease. Adipose-derived stem cells …

The role of Inflammatory mediators in the pathogenesis of obesity

E Bakinowska, M Krompiewski, D Boboryko… - Nutrients, 2024 - pmc.ncbi.nlm.nih.gov
Obesity is a pandemic of the 21st century, and the prevalence of this metabolic condition has
enormously increased over the past few decades. Obesity is associated with a number of …

Physiological changes and pathological pain associated with sedentary lifestyle-induced body systems fat accumulation and their modulation by physical exercise

E Verdú, J Homs, P Boadas-Vaello - International journal of …, 2021 - mdpi.com
A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …

An Intestinal FXR Agonist Mitigates Dysbiosis, Intestinal Tight Junctions, and Inflammation in High‐Fat Diet‐Fed Mice

TI Petito‐da‐Silva, FM Villardi… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope To analyze the effects of fexaramine (FEX), as an intestinal FXR agonist, on the
modulation of the intestinal microbiota and ileum of mice fed a high‐fat (HF) diet. Methods …

Adipo-oncology: adipocyte-derived factors govern engraftment, survival, and progression of metastatic cancers

S Sato - Cell Communication and Signaling, 2024 - Springer
Conventional therapies for metastatic cancers have limited efficacy. Recently, cancer
therapies targeting noncancerous cells in tumor microenvironments have shown improved …

The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

F Michetti, G Di Sante, ME Clementi, F Valeriani… - International Journal of …, 2024 - mdpi.com
The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also
present in other districts. Among these, the adipose tissue is a site of concentration for the …

Physiological mechanisms of TLR4 in glucolipid metabolism regulation: Potential use in metabolic syndrome prevention

F Zeng, J Zheng, L Shen… - Nutrition, Metabolism …, 2023 - Elsevier
Over-nourishment or an unbalanced diet has been linked to an increase in the prevalence of
metabolic syndrome. An imbalance in glucolipid metabolism is a major cause of metabolic …