Patient-derived cancer models: Valuable platforms for anticancer drug testing
Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with
demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority …
demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority …
The emerging role of cancer nanotechnology in the panorama of sarcoma
L Mercatali, S Vanni, G Miserocchi… - … in bioengineering and …, 2022 - frontiersin.org
In the field of nanomedicine a multitude of nanovectors have been developed for cancer
application. In this regard, a less exploited target is represented by connective tissue …
application. In this regard, a less exploited target is represented by connective tissue …
A rationale for the activity of bone target therapy and tyrosine kinase inhibitor combination in giant cell tumor of bone and desmoplastic fibroma: translational …
Giant cell tumor of bone (GCTB) and desmoplastic fibroma (DF) are bone sarcomas with
intermediate malignant behavior and unpredictable prognosis. These locally aggressive …
intermediate malignant behavior and unpredictable prognosis. These locally aggressive …
Systemic inflammatory indices in second-line soft tissue sarcoma patients: focus on lymphocyte/monocyte ratio and trabectedin
Simple Summary High NLR, PLR, and SII are associated with worse PFS in second-line STS
patients. Trabectedin-treated patients have a better PFS when LMR is low, while patients …
patients. Trabectedin-treated patients have a better PFS when LMR is low, while patients …
NELL1 regulates the matrisome to promote osteosarcoma progression
Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides
instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a …
instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a …
Unveiling the genomic basis of chemosensitivity in sarcomas of the extremities: An integrated approach for an unmet clinical need
Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) can be
considered as a spectrum of the same disease entity, representing one of the most common …
considered as a spectrum of the same disease entity, representing one of the most common …
Case report: adult NTRK-rearranged spindle cell neoplasm: early tumor shrinkage in a case with bone and visceral metastases treated with targeted therapy
Background NTRK (neurotrophic tyrosine receptor kinase)-rearranged spindle cell
neoplasms are a new group of tumors included in the new 5th edition of the World Health …
neoplasms are a new group of tumors included in the new 5th edition of the World Health …
Targeted therapies for the treatment of soft tissue sarcoma
JW Fuchs, BC Schulte, JR Fuchs, M Agulnik - Frontiers in Oncology, 2023 - frontiersin.org
Soft tissue sarcomas are rare malignant tumors derived from mesenchymal cells that have a
high morbidity and mortality related to frequent occurrence of advanced and metastatic …
high morbidity and mortality related to frequent occurrence of advanced and metastatic …
Clinical and translational implications of immunotherapy in sarcomas
Immunotherapy has emerged as promising treatment in sarcomas, but the high variability in
terms of histology, clinical behavior and response to treatments determines a particular …
terms of histology, clinical behavior and response to treatments determines a particular …
A modular composite device of poly (ethylene oxide)/poly (butylene terephthalate)(PEOT/PBT) nanofibers and gelatin as a dual drug delivery system for local therapy …
In the clinical management of solid tumors, the possibility to successfully couple the
regeneration of injured tissues with the elimination of residual tumor cells left after surgery …
regeneration of injured tissues with the elimination of residual tumor cells left after surgery …