Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …

The ten-eleven translocation (TET) family of enzymes were originally cloned from the
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …

During the past decade, we have learnt that the most common DNA modification, 5-
methylcytosine (5mC), playing crucial roles in development and disease, is not stable but …

Immunotherapies blocking negative immune checkpoints are now approved for the
treatment of a growing number of cancers. However, even in metastatic melanoma, where …

The acknowledgment that pollutants might influence the epigenome raises serious concerns
regarding their long-term impact on the development of chronic diseases. The herbicide …

Background: Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting
estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal …

Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The
role of epigenetic and epitranscriptomic alterations in cancer origin and progression has …

Metastasis formation requires active energy production and is regulated at multiple levels by
mitochondrial metabolism. The hyperactive metabolism of cancer cells supports their …

Melanoma is an aggressive neoplasia issued from the malignant transformation of
melanocytes, the pigment-generating cells of the skin. It is responsible for about 75% of …

Melanoma is a malignant tumor of melanocytes and is considered to be the most aggressive
cancer among all skin diseases. The pathogenesis of melanoma has not been well …