Metabolic and ionic control of T cells in asthma endotypes

T Franz, S Stegemann-Koniszewski… - … of Physiology-Cell …, 2024 - journals.physiology.org
CD4+ T cells play a central role in orchestrating the immune response in asthma, with
dysregulated ion channel profiles and altered metabolic signatures contributing to disease …

Interactions between calcium regulatory pathways and mechanosensitive channels in airways

Y Yao, NA Borkar, M Zheng, S Wang… - Expert Review of …, 2023 - Taylor & Francis
Introduction Asthma is a chronic lung disease influenced by environmental and inflammatory
triggers and involving complex signaling pathways across resident airway cells such as …

IFN-γ–producing TH1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjögren's disease

YH Wang, W Li, M McDermott, GY Son… - Science Translational …, 2024 - science.org
Sjögren's disease (SjD) is an autoimmune disorder characterized by progressive salivary
and lacrimal gland dysfunction, inflammation, and destruction, as well as extraglandular …

Anti-Inflammatory Effects of Alphitolic Acid Isolated from Agrimonia coreana Nakai Extracts Are Mediated via the Inhibition of ICRAC Activity in T Cells

SJ Park, JS Lee, YR Nam, JM Lee, DW Ki… - International Journal of …, 2023 - mdpi.com
Agrimonia pilosa Ledeb., an important medicinal herb in traditional East Asian medicine, is
primarily used to treat abdominal pain, dysentery, and hemostasis. There are ten other …

Channel plan: control of adaptive immune responses by pannexins

I Santiago-Carvalho, M Ishikawa, HB da Silva - Trends in Immunology, 2024 - cell.com
The development of mammalian adaptive (ie, B and T cell-mediated) immune responses is
tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from …

Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease

A Jairaman, M Prakriya - Arteriosclerosis, thrombosis, and vascular …, 2024 - Am Heart Assoc
Airway epithelial cells play an indispensable role in protecting the lung from inhaled
pathogens and allergens by releasing an array of mediators that orchestrate inflammatory …

Synthetic Biology Meets Ca2+ Release-Activated Ca2+ Channel-Dependent Immunomodulation

B Bacsa, V Hopl, I Derler - Cells, 2024 - mdpi.com
Many essential biological processes are triggered by the proximity of molecules. Meanwhile,
diverse approaches in synthetic biology, such as new biological parts or engineered cells …

Recurrent respiratory papillomatosis: Immunological mechanisms involved in recurrence

KK López-Aguilar, ME Vargas-Camaño… - International Reviews …, 2024 - Taylor & Francis
Recurrent respiratory papillomatosis is a benign neoplastic pathology in children, young
people, and adults. It causes a significant deterioration in the quality of life, with symptoms …

Synthetic Biology Meets Ca2+ Release-Activated Ca2+ Channel-Dependent Immunomodulation

I Derler, B Bacsa, V Hopl - Cells, 2024 - epub.jku.at
Many essential biological processes are triggered by the proximity of molecules. Meanwhile,
diverse approaches in synthetic biology, such as new biological parts or engineered cells …

Inhibition of γ-glutamyl transferase suppresses airway hyperresponsiveness and airway inflammation in a mouse model of steroid resistant asthma exacerbation

C Zhang, H Xu, KG Netto, LA Sokulsky, Y Miao… - Frontiers in …, 2023 - frontiersin.org
Introduction Despite recent advances, there are limited treatments available for acute
asthma exacerbations. Here, we investigated the therapeutic potential of GGsTop, a γ …