[HTML][HTML] uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

MA Pavón, I Arroyo-Solera, MV Céspedes… - Oncotarget, 2016 - ncbi.nlm.nih.gov
There is strong evidence supporting the role of the plasminogen activator system in head
and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase …

[HTML][HTML] Structural biology and protein engineering of thrombolytics

J Mican, M Toul, D Bednar, J Damborsky - Computational and structural …, 2019 - Elsevier
Myocardial infarction and ischemic stroke are the most frequent causes of death or disability
worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used …

Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin

V De Lorenzi, GM Sarra Ferraris, JB Madsen… - EMBO …, 2016 - embopress.org
Components of the plasminogen activation system including urokinase (uPA), its inhibitor
(PAI‐1) and its cell surface receptor (uPAR) have been implicated in a wide variety of …

Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites

DM Dupont, CK Thuesen, KA Bøtkjær, MA Behrens… - PloS one, 2015 - journals.plos.org
Nucleic acid aptamer selection is a powerful strategy for the development of regulatory
agents for molecular intervention. Accordingly, aptamers have proven their diligence in the …

Система активатора плазминогена урокиназного типа в норме и при жизнеугрожающих процессах (обзор)

ЕВ Кугаевская, ТА Гуреева, ОС Тимошенко… - Общая …, 2018 - cyberleninka.ru
Многофункциональная система активатора плазминогена урокиназного типа (uPA-
система) включает сериновую протеиназу—uPA или урокиназу, ее рецептор—uPAR и …

Targeting Tumor Cell Invasion and Dissemination In Vivo by an Aptamer That Inhibits Urokinase-type Plasminogen Activator through a Novel Multifunctional …

KA Botkjaer, EI Deryugina, DM Dupont… - Molecular Cancer …, 2012 - AACR
Data accumulated over the latest two decades have established that the serine protease
urokinase-type plasminogen activator (uPA) is a potential therapeutic target in cancer. When …

The shapes of Z-α1-antitrypsin polymers in solution support the C-terminal domain-swap mechanism of polymerization

MA Behrens, TJ Sendall, JS Pedersen, M Kjeldgaard… - Biophysical …, 2014 - cell.com
Emphysema and liver cirrhosis can be caused by the Z mutation (Glu342Lys) in the serine
protease inhibitor α1-antitrypsin (α1AT), which is found in more than 4% of the Northern …

A marine fibrinolytic compound FGFC1 stimulating enzymatic kinetic parameters of a reciprocal activation system based on a single chain urokinase-type plasminogen …

R Guo, D Duan, S Hong, Y Zhou, F Wang, S Wang… - Process …, 2018 - Elsevier
A marine fibrinolytic compound FGFC1 enhancing fibrinolysis was obtained involving
enzymatic kinetic parameters of a reciprocal activation system with a single chain urokinase …

[HTML][HTML] Urokinase-Type Plasminogen Activator System in Norm and in Life-Threatening Processes

EV Kugaevskaya, TA Gureeva… - General …, 2018 - reanimatology.com
The multifunctional urokinase-type plasminogen activator system (uPA-system) includes
serine proteinase—uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI …

The mixture of poly(propylene-glycol)-block-poly(ethylene-glycol)-block-PPG with C12E5 microemulsion

S Sharifi, GV Jensen, JS Pedersen, O Marti… - … and Chemistry of …, 2014 - Taylor & Francis
We study oil-in-water microemulsions, in particular dispersions of n-decane droplets coated
with a monolayer of the surfactant C12E5 in a continuous phase of water. Upon addition of …