CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
HIV‐associated chronic immune activation
M Paiardini, M Müller‐Trutwin - Immunological reviews, 2013 - Wiley Online Library
Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and
mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional …
mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional …
Natural SIV hosts: showing AIDS the door
Many species of African nonhuman primates are naturally infected with simian
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …
Reservoir host immune responses to emerging zoonotic viruses
Zoonotic viruses, such as HIV, Ebola virus, coronaviruses, influenza A viruses, hantaviruses,
or henipaviruses, can result in profound pathology in humans. In contrast, populations of the …
or henipaviruses, can result in profound pathology in humans. In contrast, populations of the …
Key viral adaptations preceding the AIDS pandemic
D Sauter, F Kirchhoff - Cell host & microbe, 2019 - cell.com
HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-
species transmissions and recombination events as well as changes in the repertoire and …
species transmissions and recombination events as well as changes in the repertoire and …
Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression
M Paiardini, B Cervasi, E Reyes-Aviles, L Micci… - Nature medicine, 2011 - nature.com
Naturally simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to
AIDS despite high-level virus replication. We previously showed that the fraction of CD4+ …
AIDS despite high-level virus replication. We previously showed that the fraction of CD4+ …
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection
M Muenchhoff, E Adland, O Karimanzira… - Science translational …, 2016 - science.org
Disease-free infection in HIV-infected adults is associated with human leukocyte antigen–
mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural …
mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural …
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts
DL Sodora, JS Allan, C Apetrei, JM Brenchley… - Nature medicine, 2009 - nature.com
The design of an effective AIDS vaccine has eluded the efforts of the scientific community to
the point that alternative approaches to classic vaccine formulations have to be considered …
the point that alternative approaches to classic vaccine formulations have to be considered …
Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: a review
MP Girard, S Osmanov, OM Assossou, MP Kieny - Vaccine, 2011 - Elsevier
The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …