The X-linked gene encoding MECP2 is involved in two severe and complex
neurodevelopmental disorders. Loss of function of the MeCP2 protein underlies Rett …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …

Brain organoids represent a powerful tool for studying human neurological diseases,
particularly those that affect brain growth and structure. However, many diseases manifest …

Exosomes are thought to be released by all cells in the body and to be involved in
intercellular communication. We tested whether neural exosomes can regulate the …

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome. MeCP2 is
thought to regulate gene transcription by binding to methylated DNA broadly across the …

Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the
hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's …

Duplication of methyl-CpG-binding protein 2 (MECP2) gene causes MECP2 duplication
syndrome (MDS). To normalize the duplicated MECP2 in MDS, we developed a high-fidelity …

MECP2 gene transfer has been shown to extend the survival of Mecp2−/y knockout mice
modelling Rett syndrome, an X-linked neurodevelopmental disorder. However, controlling …

With the recent 50th anniversary of the first publication on Rett syndrome, and the almost 20
years since the first report on the link between Rett syndrome and MECP2 mutations, it is …

Aims To investigate associations between functioning, community participation, and quality
of life (QoL) and identify whether participation mediates the effects of functioning on QoL …