Xeloda (capecitabine), a thymidine phosphorylase activated fluoropyrimidine carbamate, is
currently the only universally approved orally administered 5-fluorouracil (5-FU) prodrug. It …

Abstract Capecitabine (N 4-pentyloxycarbonyl-5-deoxy-5-fluorocytidine), an oral prodrug of
5-fluorouracil, has provided compelling efficacy data for the treatment of metastatic breast …

Canine mammary tumours are generally treated with surgery alone, despite the fact that
50% of them are malignant and many will eventually lead to recurrence or metastases. A …

Background: This multicentre, international phase II trial evaluated the efficacy and safety
profile of a first-line combination of oral vinorelbine plus capecitabine for women with …

Purpose Combination of intravenous (iv) vinorelbine and capecitabine was shown to be
feasible and effective in metastatic breast cancer (MBC). In an effort to improve patient …

The therapeutic landscape for metastatic breast cancer (MBC) has expanded greatly over
the last three decades with an increasing availability of targeted therapies for specific breast …

Purpose To determine the dose-limiting toxicities (DLTs) and the maximum tolerated doses
(MTD) of oral metronomic vinorelbine with capecitabine in patients with metastatic breast …

BACKGROUND: As anthracyclines and taxanes are frequently used in the adjuvant and first-
line metastatic settings, capecitabine and vinorelbine are frequently used as monotherapy …

Purpose The aim of this study was to evaluate the efficacy and safety of capecitabine in
combination with vinorelbine in patients with metastatic breast cancer (MBC) pretreated with …

Purpose Effective treatment options for patients with metastatic breast cancer (MBC)
resistant/refractory to anthracyclines and/or taxanes are limited. Intravenous and oral …