Molecular changes and signaling events occurring in spermatozoa during epididymal maturation

MG Gervasi, PE Visconti - Andrology, 2017 - Wiley Online Library
After leaving the testis, spermatozoa have not yet acquired the ability to move progressively
and are unable to fertilize oocytes. To become fertilization competent, they must go through …

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 5: intercellular junctions and contacts between germs cells and Sertoli …

L Hermo, RM Pelletier, DG Cyr… - Microscopy Research …, 2010 - Wiley Online Library
In the testis, cell adhesion and junctional molecules permit specific interactions and
intracellular communication between germ and Sertoli cells and apposed Sertoli cells …

Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma

AP Drabovich, A Dimitromanolakis, P Saraon… - Science translational …, 2013 - science.org
Male fertility problems range from diminished production of sperm, or oligozoospermia, to
nonmeasurable levels of sperm in semen, or azoospermia, which is diagnosed in nearly 2 …

Proteomic analysis of seminal plasma from normal volunteers and post-vasectomy patients identifies over 2000 proteins and candidate biomarkers of the urogenital …

I Batruch, I Lecker, D Kagedan, CR Smith… - Journal of proteome …, 2011 - ACS Publications
Seminal plasma is a fluid that originates from the testis, epididymis, prostate, and seminal
vesicles, and hence, proteomic studies may identify potential markers of infertility and other …

Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa

Y Fujihara, K Tokuhiro, Y Muro… - Proceedings of the …, 2013 - National Acad Sciences
Formation of spermatozoa of normal shape, number, and motility is insufficient for the male
siring of pups. The spermatozoa must be accompanied by sound fertilizing ability. We found …

Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay

AP Drabovich, K Jarvi, EP Diamandis - Molecular & Cellular Proteomics, 2011 - ASBMB
Seminal plasma is a promising biological fluid to use for noninvasive clinical diagnostics of
male reproductive system disorders. To verify a list of prospective male infertility biomarkers …

A role of the TEX101 interactome in the common aetiology behind male subfertility and testicular germ cell tumor

J Burton, MW Wojewodzic, TB Rounge… - Frontiers in …, 2022 - frontiersin.org
Patients who develop testicular germ cell tumours (TGCT) are at higher risk to be subfertile
than the general population. The conditions are believed to originate during foetal life …

Elevated expression levels of testis‐specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features

S Ghafouri‐Fard, A Abbasi, H Moslehi… - British Journal of …, 2010 - academic.oup.com
Background Basal cell carcinoma (BCC) is characterized by a low rate of metastasis, slow
growth and strong stroma dependency, with significant morbidity and public health burden …

[HTML][HTML] An emerging role of TEX101 protein as a male infertility biomarker

CG Schiza, K Jarv, EP Diamandis, AP Drabovich - Ejifcc, 2014 - ncbi.nlm.nih.gov
Infertility is an important aspect of human reproduction. It affects up to 15% of couples, with
the male factor contributing to approximately 50% of all cases. Azoospermia is one of the …

Mapping the human sperm proteome–novel insights into reproductive research

MA Miyazaki, RL Guilharducci, P Intasqui… - Expert Review of …, 2023 - Taylor & Francis
Introduction Spermatozoa are highly specialized cells with unique morphology. In addition,
spermatozoa lose a considerable amount of cytoplasm during spermiogenesis, when they …