The core planar polarity pathway consists of six proteins that form asymmetric intercellular
complexes that segregate to opposite cell ends in developing tissues and specify polarized …

Background The Prickle2 (Pk2) gene shows promising potential in uncovering the
underlying causes of epilepsy, a neurological disorder that is currently not well understood …

Planar cell polarity (PCP) is an evolutionarily conserved process for development and
morphogenesis in metazoans. The well-organized polarity pattern in cells is established by …

Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along
the epithelial plane perpendicular to the apical-basal direction, which is important for tissue …

Developmental studies have shown that the evolutionarily conserved Wnt Planar Cell
Polarity (PCP) pathway is essential for the development of a diverse range of tissues and …

Actomyosin contractility represents an ancient feature of eukaryotic cells participating in
many developmental and homeostasis events, including tissue morphogenesis, muscle …

Planar cell polarity (PCP) signaling polarizes epithelial cells within the plane of an
epithelium. Core PCP signaling components adopt asymmetric subcellular localizations …

Wnt family proteins are secreted glycolipoproteins that signal through multitude of signal
transduction pathways. The Wnt-pathways are conserved and critical in all metazoans. They …

Convergent extension (CE) is a fundamental morphogenetic process where oriented cell
behaviors lead to polarized extension of diverse tissues. In vertebrates, regulation of CE …

A broad spectrum of human birth defects arise from the disruption of morphogenesis, the
critical process through which tissues and organs acquire their proper shape. Convergent …