Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production–a critical review

A Kumar, KV Gernaey, T De Beer, I Nopens - European Journal of …, 2013 - Elsevier
The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-
wise process, is now also transformed into a series of continuous operations. Some …

A review of monitoring methods for pharmaceutical wet granulation

EM Hansuld, L Briens - International journal of pharmaceutics, 2014 - Elsevier
High-shear wet granulation is commonly used in the pharmaceutical industry to improve
powder properties for downstream processes such as tabletting. Granule growth, however …

Lightweight aggregates produced by granulation of peat-wood fly ash with alkali activator

J Yliniemi, H Nugteren, M Illikainen, M Tiainen… - International Journal of …, 2016 - Elsevier
This study presents a new method to produce lightweight aggregates (LWAs) by granulating
peat-wood ash using alkali activators. Peat-wood ash was granulated with potassium …

Scale-up of high shear mixer-granulator based on discrete element analysis

H Nakamura, H Fujii, S Watano - Powder Technology, 2013 - Elsevier
For developing a scale-up method based on the kinematic and dynamic similarities of
particle behavior, motion of particles in a commercial high shear mixer-granulator with …

Experimental studies on distributions of granule size, binder content and porosity in batch drum granulation: Inferences on process modelling requirements and …

R Ramachandran, JMH Poon, CFW Sanders… - Powder Technology, 2008 - Elsevier
Batch granulation experiments on a lab-scale drum granulator for a Calcite/Polyvinyl alcohol
in water (Calcite/PVOH–H2O) system are presented in this study. Experimental studies were …

Coarse-grained discrete element simulation of particle flow and mixing in a vertical high-shear mixer

N Kishida, H Nakamura, H Takimoto, S Ohsaki… - Powder Technology, 2021 - Elsevier
There is a huge demand for the development of a coarse-grained model of a discrete
element method (DEM) to perform a numerical simulation of a high-shear mixer with large …

Dry mixing of cathode composite powder for all-solid-state batteries using a high-shear mixer

E Hayakawa, H Nakamura, S Ohsaki… - Advanced Powder …, 2022 - Elsevier
All-solid-state lithium-ion batteries (ASSLIBs) are promising candidates for next-generation
batteries because of their various attractive properties. The uniform mixing of active …

Granulation of increasingly hydrophobic formulations using a twin screw granulator

S Yu, GK Reynolds, Z Huang, M de Matas… - International journal of …, 2014 - Elsevier
The application of twin screw granulation in the pharmaceutical industry has generated
increasing interest due to its suitability for continuous processing. However, an …

Impact of impeller design on high-shear wet granulation

M Börner, M Michaelis, E Siegmann, C Radeke… - Powder Technology, 2016 - Elsevier
In recent decades, three-blade impellers have been well-established in pharmaceutical high-
shear granulation. However, three-blade impellers often require high rotation speeds to …

In-line size monitoring of a twin screw granulation process using high-speed imaging

AS El Hagrasy, P Cruise, I Jones, JD Litster - Journal of Pharmaceutical …, 2013 - Springer
Purpose This study aimed to evaluate the feasibility of implementing a 3D high-speed
imaging camera for in-line monitoring of a continuous wet granulation process and its …