Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …

Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Experimental in vitro models that capture pathophysiological characteristics of human
tumours are essential for basic and translational cancer biology. Here, we describe a fully …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …