Target protein identification is the key to identification of the mechanisms, side effects, and
evaluating druglikeness of small-molecule drugs. The commonly used “labeled” target …

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and
pathological processes, rendering them promising targets for drug discovery. GPCRs …

Drug discovery aims at finding promising drug molecules for treating target diseases.
Existing computational drug discovery methods mainly depend on molecule databases …

Enzymes, which are biological molecules, are constructed from polypeptide chains, and
these molecules are activated through reaction mechanisms. It is the role of enzymes to …

Asthma is a chronic disease that is caused by airway inflammation. The main features of
asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The …

Inherited axonopathies represent a spectrum of disorders unified by the common
pathological mechanism of length-dependent axonal degeneration. Progressive axonal …

Highlights•Evolutionary insights are helpful in various medical fields.•HARs are significantly
enriched with neurological disorder-associated genes.•Approved drugs target nearly twice …

Due to synergistic effects, combinatorial drugs are widely used for treating complex
diseases. However, combining drugs and making them synergetic remains a challenge …

Background: Patients with Varicose veins (VV) show no obvious symptoms in the early
stages, and it is a common and frequent clinical condition. DNA methylation plays a key role …

The development of an innovative drug is complex and time-consuming, and the drug target
identification is one of the critical steps in drug discovery process. Effective and accurate …